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FDA greenlights a new type of drug for menopausal hot flashes

Published Wed, 19 Mar 2025 19:18:50 GMT

(CNN) — The US Food and Drug Administration on Friday approved a new type of drug to treat hot flashes and night sweats during menopause.Veozah, or fezolinetant, made by Astellas Pharma, is the first approved neurokinin 3 (NK3) agonist. It blocks receptors in the brain that play a role in the regulation of body temperature. It’s an alternative to traditional hormone replacement therapies to manage hot flashes, which are a common symptom of menopause that can be disruptive if they become severe.Women at higher risk of stroke, heart attacks or some kinds of cancer are sometimes advised against using hormone replacement therapies because they increase the risk of blood clots and cancers.“Hot flashes as a result of menopause can be a serious physical burden on women and impact their quality of life,” said Dr. Janet Maynard, director of the FDA’s Office of Rare Diseases, Pediatrics, Urologic and Reproductive Medicine in the Center for Drug Evaluation an...

Turkey presidential election will go to runoff as Erdogan performs better than expected

Published Wed, 19 Mar 2025 19:18:50 GMT

By SUZAN FRASER and ZEYNEP BILGINSOY (Associated Press)ANKARA, Turkey (AP) — Turkey’s presidential election will be decided in a runoff, election officials said Monday, after incumbent Recep Tayyip Erdogan pulled ahead of his chief challenger, but fell short of an outright victory that would extend his increasingly authoritarian rule into a third decade.The May 28 second-round vote will determine whether the strategically located NATO country remains under the president’s firm grip or can embark on a more democratic course promised by his main rival, Kemal Kilicdaroglu.While Erdogan has governed for 20 years, opinion polls had suggested that run could be coming to an end and that a cost-of-living crisis and criticism over the government’s response to a devastating February earthquake might redraw the electoral map.Instead, Erdogan’s retreat was still less marked than predicted — and with his alliance retaining its hold on the parliament, he is now in a good position to win in the se...

Motorcyclist killed in North County crash

Published Wed, 19 Mar 2025 19:18:50 GMT

ESCONDIDO, Calif. — A man was killed Sunday night after he crashed his motorcycle in North County, the Escondido Police Department said.The crash happened around 10 p.m. in the 600 block of North Escondido Boulevard, north of Washington Avenue.For reasons still under investigation, the motorcyclist left the roadway and struck a light pole, police said. Afghan on terror watch list reportedly arrested near San Diego border Upon arrival, officers found the man unresponsive and administered CPR before medics transported him to a nearby hospital, where he was later pronounced dead.It is not yet known if speed, alcohol or drugs were a factor in the crash, according to officials.The identity of the man has not yet been publicly released by the San Diego County Medical Examiner's Office.Anyone with information or who may have witnessed the crash was asked to contact Office Jake Houchin at 760-839-4704.

Stock market today: Wall Street holds steady ahead of retail sales data

Published Wed, 19 Mar 2025 19:18:50 GMT

NEW YORK (AP) — Wall Street is drifting ahead of a week that will show how much a slowing economy and other worries are hitting the backbone of the U.S. economy: spending by households. The S&P 500 was hoverering around breakeven early Monday in its first trading after closing out a second straight down week. The Dow Jones Industrial Average also little changed while the Nasdaq composite was up 0.1%. Some of the sharper moves came from companies announcing takeovers of rivals, including an 8% drop for energy company Oneok after it said it’s buying Magellan Midstream Partners. Magellan jumped 14%.THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below.Wall Street appeared headed for gains early Monday ahead of a busy week in retail, with a backdrop of debt ceiling negotiations between President Joe Biden and Republican lawmakers.Futures for the Dow Jones industrials and the S&P 500 rose 0.4% before the bell.Home Depot, Target and Walmart report earnings this week, wh...

Supreme Court to review Democratic lawmakers’ suit over Trump hotel lease

Published Wed, 19 Mar 2025 19:18:50 GMT

WASHINGTON (AP) — The Supreme Court on Monday agreed to hear a Biden administration appeal to limit lawsuits filed by members of Congress against the federal government, in a case that stems from disputes over what was the Trump International Hotel in Washington.The justices said they will review a federal appeals court ruling that allowed a suit by Democratic members of the House Oversight Committee to continue. They filed their complaint in 2017 over the Trump administration’s refusal to turn over information about the Trump Organization’s lease of the hotel on Pennsylvania Avenue, between the White House and the Capitol.The family no longer owns the hotel, now a Waldorf Astoria, much of the information eventually was provided and six lawmakers who were part of the case no longer serve in the House.The Biden Justice Department, however, told the court that it is important to wipe the appellate ruling from the books because it otherwise could lead to a flood of lawsuits...

Supreme Court to review South Carolina congressional map for discrimination against Black voters

Published Wed, 19 Mar 2025 19:18:50 GMT

WASHINGTON (AP) — The Supreme Court has agreed to decide whether South Carolina’s congressional districts need to be redrawn because they discriminate against Black voters.The justices said Monday they would review a lower-court ruling that found a coastal district running from Charleston to Hilton Head was intentionally redrawn to reduce the number of Democratic-leaning Black voters and to make it more likely Republican candidates would win. The case probably will be argued in the fall, and decided in the run up to the 2024 elections, when all the seats in the closely divided House of Representatives, now under Republican control, will be on the ballot. The three-judge court that ruled in favor of civil rights groups that challenged the congressional map said in its opinion in January that the districts violated the federal Voting Rights Act by unfairly diluting the power of Black voters.The Supreme Court has cut back on the reach of the landmark voting rights law, and is now...

NATO mulls future security guarantees for Ukraine but wary of igniting a wider war

Published Wed, 19 Mar 2025 19:18:50 GMT

BRUSSELS (AP) — NATO leaders are discussing ways to ensure that Ukraine does not come under attack from Russia again once the war is over, but they are concerned about doing anything that might drag the organization into a wider conflict, the head of the military alliance said Monday. Ukrainian President Volodymyr Zelenskyy is seeking “security guarantees” from the 31-nation alliance to ward off any future attack from Ukraine’s neighbor. Some countries are weighing what could be done to avoid a repeat of the war. Russia already annexed the Crimean Peninsula in 2014.“There are consultations that are going on,” ahead of a summit involving U.S. President Joe Biden and his counterparts in Lithuania on July 11-12, NATO Secretary-General Jens Stoltenberg said during an interview with his predecessor, Anders Fogh Rasmussen, at a conference in Copenhagen.Stoltenberg declined to provide details about those talks.NATO allies benefit from a collective security guarantee — so called Article 5 o...

Philadelphia Democratic mayoral primary pits moderates against progressives

Published Wed, 19 Mar 2025 19:18:50 GMT

A Democratic primary that will likely determine who becomes Philadelphia’s next mayor could boost a progressive cause struggling to make a comeback after national setbacks, but with no clear front-runner it’s just as likely to fortify the city’s existing Democratic machine. Not one of the five top candidates has emerged as a clear favorite in Tuesday’s primary, a digression from mayoral races in recent history, said Richardson Dilworth, author of the book “Reforming Philadelphia,” which examines the city’s government over the course of 350 years.“The political structure of the city is in a moment that is somewhat unprecedented,” he said. “It’s ideologically incredibly cohesive. But … there’s nothing taking that cohesive ideology and converting it into a unified governance for the city.”The progressive movement — which has focused on local races to counter national setbacks — has its sights on the Philadelphia race after being energized by Chicago Mayor Brando...

April’s national home sales up 11.3% from March: CREA

Published Wed, 19 Mar 2025 19:18:50 GMT

OTTAWA — The Canadian Real Estate Association says national home sales jumped by 11.3 per cent between March and April as the real estate market picked up again.The association says seasonally-adjusted sales for the month totalled 38,164 compared with 34,277 in March.The actual number of homes sold last month amounted to 44,059, down 19.5 per cent from a year prior. The association says the year-over-year sales decline was markedly smaller than the drops reported in recent months.The seasonally-adjusted number of new listings edged up 1.6 per cent to 54,355 in April from March, but supply remains at a 20-year low.The actual average home price reached roughly $716,000 in April, down 3.9 per cent from April 2022, but up $103,500 from January 2023.This report by The Canadian Press was first published May 15, 2023.The Canadian Press

Statistics Canada says wholesale sales excluding petroleum down 0.1 per cent in March

Published Wed, 19 Mar 2025 19:18:50 GMT

OTTAWA — Statistics Canada says wholesale sales excluding petroleum fell 0.1 per cent to $85.6 billion in March, led by a drop in the miscellaneous subsector and the machinery equipment and supplies subsector. Overall, sales fell in four of the seven subsectors tracked by the agency. Statistics Canada says sales in the miscellaneous subsector fell 6.1 per cent to $11.4 billion as sales in the agricultural supplies industry group fell 15.5 per cent to $4.1 billion.The machinery, equipment and supplies subsector dropped 2.0 per cent to $18.0 billion in March as the computer and communications equipment and supplies industry group fell 9.2 per cent to $4.9 billion,Sales from the farm product subsector rose 19.1 per cent to $4.7 billion.Constant dollar sales excluding petroleum fell 0.3 per cent in March.This report by The Canadian Press was first published May 15, 2023.The Canadian Press